How Ozempic works for inflammation Archives

At Group23, we often hear a familiar and deeply understandable concern from our patients:

“I know I need to exercise as part of my comprehensive management strategy for my knee or hip osteoarthritis, but it’s so hard to lose weight when movement itself causes pain and inflammation. Would it be OK if I took Ozempic to help with my weight?”

This question is not only valid—it’s important. Osteoarthritis (OA) in weight-bearing joints like the knees, hips, and ankles is significantly influenced by excess body weight. Every pound lost translates into several pounds less pressure across the joint with each step. So yes, weight loss is powerful medicine for OA—but achieving it, especially when pain limits activity, is an uphill climb for many.

First: The Foundation Matters

At Group23, we emphasize a strong foundation in aggressive, non-operative treatment before considering more advanced or medical interventions like GLP-1 receptor agonists (e.g., Ozempic, Wegovy). Our comprehensive conservative treatment strategies include:

Education: Understanding osteoarthritis and its drivers empowers better choices. See link for more information on understanding osteoarthritis HERE.
Regular low-impact exercise: Tailored activity to improve joint function and reduce inflammation (yes, even inflamed joints can benefit from the right kind of movement).
Anti-inflammatory diet: Minimizing processed foods and emphasizing whole, plant-forward nutrition. See link for information on anti-inflammatory diet and meal ideas HERE.
Judicious NSAID use: Non-steroidal anti-inflammatory drugs (Advil/Ibuprofen, Aleve/Naproxen, Voltaren/Diclofenac, Celebrex etc) when used appropriately, can support function—but they’re not the long-term answer.
Bracing and unloading strategies: Offload the affected joint to improve movement tolerance.
Physiotherapy: Not just exercise—manual therapy, movement retraining, and progressive strength building under supervision of a G23 Physiotherapist with specialized knowledge in OA rehabilitation.
Injection therapies: PRP (Platelet Rich Plasma), hyaluronic acid, and cortisone can help reduce inflammation and pain enough to allow patients to move again.

These are all evidence-based tools that work in synergy. But we acknowledge the reality: if your pain prevents you from moving, weight loss becomes incredibly hard—and yet, without weight loss, OA continues to progress.

Where Does Ozempic Fit In?

GLP-1 medications like Ozempic were developed for diabetes but are now increasingly used for weight management. They work by reducing appetite and improving insulin sensitivity, often resulting in significant weight loss.

Emerging evidence suggests that these medications may also have an indirect benefit on OA progression—not by modifying the joint disease directly, but by reducing the mechanical and inflammatory burden on the joint through weight loss. However, there are some caveats:

Rapid weight loss can result in loss of lean mass unless counteracted with appropriate exercise and protein intake.
Some reports suggest potential impacts on bone density—particularly in older adults or those already at risk of osteoporosis.
The long-term effects on joint tissue specifically have not been fully studied yet.

So, should we use Ozempic as part of OA management? The short answer: sometimes, and with the right intention.

The Most Important Factor: Your Goal

At Group23, we don’t believe in prescribing treatments just because they’re available. Everything starts with your “RiseAbove Goal”—a clear, SMART (Specific, Measurable, Achievable, Relevant, and Time-bound) goal that reflects what you want to achieve. Whether it’s:

“I want to be able to walk 30 minutes daily without stopping”
“I want to return to hiking with my family this summer”
“I want to delay knee surgery for at least 3 years”

This goal becomes the benchmark for evaluating whether a treatment is helping—not whether the pain score is lower, or the x-ray looks better, but whether you’re closer to the life you want to live.

Ozempic, in this light, isn’t a shortcut or magic bullet. It’s a potential tool, used in service of your goal, not instead of all the other conservative care strategies that build long-term success.

A Reasonable Approach to Weight Loss

If you’re struggling to lose weight because movement is painful, and you’ve already made efforts to optimize diet, exercise, and other treatments, then a conversation about GLP-1 medications is reasonable. This medication might be the bridge that reduces load enough to get you moving again—to make that daily walk possible, to help you say yes to your goals.

But it should be:

Part of a multidisciplinary plan
Closely monitored
Focused on sustainable change, not just numbers on a scale
Used alongside a program that preserves muscle, supports bone health, and keeps you moving

In Summary

Weight loss is essential in managing OA of weight-bearing joints—but it’s often very difficult, especially when movement hurts.
Ozempic may be a helpful tool for some patients—but only after exhausting conservative, non-pharmacologic strategies.
Any decision to start this medication should be made with your RiseAbove Goal in mind, not dictated by a provider.
The role of Ozempic is not to replace exercise and diet—but to support and enable those strategies when barriers like pain make them difficult to follow.

If your OA treatment plan isn’t aligned with your goals, it’s time to rethink the plan.

Let’s work together to build a strategy that helps you RiseAbove. Learn more